??, 2025?10?31? - (????) - ?????(????: 2511.HK),??????????????,?????????????????????,??HTD1801?2????(T2DM)????????III?????(SYMPHONY-1?SYMPHONY-2)??????????????????????(OLE)?52????,HTD1801??????????????????
??III??????52????????HTD1801??????,????????T2DM???????????????????????????????????(NMPA)??????(CDE)??HTD1801??T2DM??????????(NDA)?
SYMPHONY-1(NCT06350890)?SYMPHONY-2(NCT06353347)?????????????????III?????,??????HTD1801???????????????(SYMPHONY-1; N=408)??????????????(SYMPHONY-2; N=551)?T2DM???????????????????????????:??????,HTD1801??24????????(HbA1c)????????????????????28??OLE????HTD1801??????????????????52?????????,??????HTD1801???????
????????:24 ????????????,52 ????? HTD1801 ??????
SYMPHONY-1(????):HTD1801????24?HbA1c?????????-1.3%,?????????????HTD1801???????52??HbA1c??????(-1.2%)???????????HTD1801?????,??52???HbA1c??????????-1.3%,????????????????
SYMPHONY-2(?????????):HTD1801????24?HbA1c?????????-1.2%,?????????????HTD1801???????52??HbA1c??????(-1.1%)???????????? HTD1801?????,??52??? HbA1c??????????-1.2%,??????????????
????????:HTD1801 ????????????? 52 ???????
?????,???HbA1c??(HbA1c <7.0%)??????? 52 ????????????,HTD1801 ???????????????,???????????(LDL-C)???????????(non-HDL-C)??????HTD1801?????????????????T2DM????????????????γ-??????(GGT)???C????(hs-CRP)?
??????,?????????????(eGFR)????????????????????????,? 24 ????? eGFR ???? 52 ??????,??HTD1801???????????????????????
??????????
HTD1801 ???????????????????,??????????????? HTD1801 ?????,???????????????????????
???????????,????????(IDF)????????????????????????????????????????:“???????52 ??????????,HTD1801????T2DM?????????????HTD1801???????????,?????????(AIMM),????AMPK??? NLRP3 ???????????,??????????????????????????????????????:????????,????????,?????????,?????????????????? HTD1801 ?????????????(CKM)??????,??????????????????????,????????????,???????”
??????????????????????????:“???????????????????????????T2DM ???????????,?????????????????????HTD1801???????????????????????,?????????????????????????????????????III?????,?????? HTD1801 ??????????,?????????????????????????????”
??2????(T2DM)
?????????(IDF)??,2024??5.89????(20-79?)?????,???2050????8.53?(??8???????1??????),??90%?T2DM??????????????????,2024???????1.48??,??2050????1.68?????,?????????600????,???????????????,????????????????????????,??????????????????????
??HTD1801
HTD1801?????????????,????????????(CKM)?????????HTD1801???????????(AIMM),????????????? ,????AMPK???NLRP3????????????;????????????????????????????????HTD1801??“????”???,???????????,???????????????????????????????????????????,HTD1801?????CKM???????????
话题 Press release summary
来源 HighTide Therapeutics Inc.
部门 BioTech, Healthcare & Pharm, Clinical Trials
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