NEW DELHI, Apr 13, 2026 - (ACN Newswire) - Avantor, Inc., a leading life science tools company and global provider of mission-critical products and services to the life sciences and advanced technology industries, announced that Avantor India has been appointed the exclusive distributor of Amcor Parafilm® M sealing wrap products in India. Under the agreement with Amcor, Avantor India will expand access to Parafilm M sealing and moisture-barrier solutions for laboratories, horticulture and industrial applications nationwide.

Parafilm M is a flexible, semi-transparent, wax-based film known for its stretchability of up to 200% and self-sealing properties. It molds around irregular shapes to seal containers such as beakers, flasks, plates and tubes, helping reduce evaporation and contamination risk while supporting controlled gas exchange. In routine lab workflows, it supports lab safety, contamination prevention, cell culture protection, and sample and equipment protection.

This collaboration aligns with Avantor India’s broader role in supporting research, testing, production and quality workflows through a wide portfolio spanning laboratory consumables, equipment, instruments and services. It also comes at a time when India’s scientific and industrial ecosystem continues to expand, with the Indian pharmaceutical industry being the third largest globally by volume and 11th largest by value.(1) The addition of Parafilm M further strengthens Avantor India’s lab consumables portfolio, deepening its ability to serve customers across research, testing and industrial environments with a broader and more integrated offering.

“In science, small lapses can become big delays. By bringing Parafilm M into our India distribution network, we are strengthening a critical layer of lab safety that supports repeatability, protects samples, and reduces avoidable rework. The priority will be to help customers adopt consistent sealing and storage practices that improve contamination prevention, support cell culture protection, and safeguard sample and equipment protection, with the supply reliability and support they expect from Avantor”, said Puneet Pant, Managing Director and Lab Solutions Leader, India at Avantor. “It also allows us to offer customers greater convenience through a stronger portfolio fit, dependable availability and easier access to a trusted product that complements their day-to-day laboratory workflows.”

Through Avantor India, customers will be able to procure Parafilm M products through Avantor’s distribution channel, supported by customer service and expert guidance on handling, storage and selection across common laboratory environments. The offering supports use cases such as sealing for short-term work in cold rooms and incubators, sample transport and storage, and routine workflows where chemical resistance and material compatibility considerations matter. For customers, this brings the advantage of sourcing Parafilm M through a trusted lab partner that can support product selection, streamline procurement and improve continuity across essential consumables.

“Amcor Parafilm M is trusted globally because it is reliable, easy to use and adaptable across applications,” said Ally Ostrander from Amcor. “Avantor’s reach in India will help more laboratories adopt consistent sealing practices, reduce avoidable contamination events and protect critical samples and equipment.”

In addition to distribution, Avantor India will support customers with application-led sessions on lab safety practices, including contamination prevention checkpoints, sealing techniques, and storage discipline to reduce rework. Customers can also streamline procurement by bundling Parafilm M with other critical lab supplies through a single partner.

(1) https://tvbrics.com/en/news/india-s-pharmaceutical-sector-ranks-among-global-leaders-as-exports-and-production-surge/

About Avantor®

Avantor® is a leading life science tools company and global provider of mission-critical products and services to the life sciences and advanced technology industries. We work side-by-side with customers at every step of the scientific journey to enable breakthroughs in medicine, healthcare, and technology. Our portfolio is used in virtually every stage of the most important research, development and production activities at more than 300,000 customer locations in 180 countries. For more information, find us on LinkedIn, X (Twitter) and Facebook.

Regional Media Contact
Swati Chhabra
Manager - Corporate Communications, AMEA
Avantor
91-9958-404-334
Swati.Chhabra@avantorsciences.com

Global Media Contact
Eric Van Zanten
Head - External Communications
Avantor
610-529-6219
Eric.Vanzanten@avantorsciences.com 

As the medical robotics sector continues to gain momentum, market discussion tends to center on technical specifications and commercialization progress. Yet from a long-term investment perspective, these dimensions alone cannot explain the divergence in value among companies. What truly determines a medical robotics company's long-term worth is not the technology itself—but the level of clinical problem it solves.

The global medical robotics market is projected to grow from roughly USD 70–80 billion in 2023 to over USD 200 billion by around 2030, representing a compound annual growth rate above 15%. More notable, however, is the structural shift underway: the industry's core growth driver is moving rapidly from the "surgical execution end" toward the "diagnostic gateway"—that is, earlier disease detection and more accurate early-stage diagnosis and intervention. Competition around device performance is giving way to competition around solving clinical problems themselves.

I. A Three-Tier Value Framework: Problem Level Determines Long-Term Upside

At its core, medical innovation addresses clinical problems that can be organized into three progressive tiers:

- Tier 1: Can it be done at all? — Procedures that were previously infeasible or unreliable, representing breakthroughs in clinical capability.

- Tier 2: Can it be done faster? — Corresponding to efficiency gains.

- Tier 3: Can it be done more affordably? — Corresponding to cost optimization.

Most medical robotics innovation today remains concentrated in the latter two tiers—essentially extending existing clinical capabilities. The truly scarce and defensible direction is Tier 1: using technology to make previously unachievable medical procedures safe and accurate, thereby creating breakthrough clinical value.

This logic has been validated repeatedly. The da Vinci Surgical System, with a global installed base exceeding 8,000 units and over 2 million annual procedures, owes its sustained high gross margins and steady growth to one thing: its irreplaceable ability to enable complex minimally invasive surgeries that could not otherwise be performed. The same principle applies to TAVR and electrophysiology ablation—each opened new markets by establishing entirely new clinical capabilities.

Companies that solve "can it be done at all" typically enjoy higher technological barriers, stronger pricing power, longer product lifecycles, and more pronounced valuation premiums.

II. An Overlooked Capability Gap: From Detection to Diagnosis

This framework is particularly clear in lung cancer care. Lung cancer remains one of the most prevalent and lethal malignancies worldwide, with over 2.2 million new cases and nearly 1.8 million deaths annually—accounting for more than 18% of all cancer-related mortality.

In recent years, the widespread adoption of low-dose CT screening (LDCT) has dramatically improved our ability to detect problems, with pulmonary nodule detection rates reaching 20–30% among high-risk populations. Diagnostic capability, however, has not kept pace—and has instead become a new systemic bottleneck.

Consider the challenge of peripheral lung nodules: over 65% of pulmonary nodules are located in the lung periphery, where conventional bronchoscopes face clear limitations in reaching deep-seated lesions. Compounding this, dynamic discrepancies between preoperative CT imaging and the patient's actual respiratory state introduce widespread localization errors in clinical practice.

This is not an efficiency problem. It is a capability that has yet to be established. How to reliably access targets within complex pulmonary anatomy, and how to achieve precise localization in a dynamically shifting environment—these capabilities directly determine diagnostic accuracy and safety. They represent a textbook "capability-gap opportunity."

For investors, such opportunities share distinct hallmarks: well-defined demand, clear pain points, and high technological barriers. Once a breakthrough is achieved, it typically produces durable competitive moats and extended growth cycles.

III. Noah Medical: A Strategic Entry Through the Capability Gap

As the industry migrates from "efficiency optimization" to "capability creation," Noah Medical has chosen to enter precisely through the capability gap described above—targeting the core challenge of the confirmatory diagnosis stage in early lung cancer detection, and using technology to enhance lesion access and localization, completing a critical missing link in the diagnostic chain.

The technological foundation of this approach lies in the deep integration of real-time image-based localization, AI, and robotic control systems. The Galaxy system dynamically corrects discrepancies between imaging and the patient's anatomy during the procedure, delivering higher-precision lesion localization in complex environments. This is the single most critical technical challenge in diagnosing peripheral lung nodules today.

Core Clinical Data

Since receiving FDA clearance in 2023, the Galaxy system has been used in over 10,000 clinical procedures across an installed base of more than 50 systems. Robotic navigational bronchoscopy diagnostic yield exceeds 90–93%, with a lesion localization success rate of approximately 96% and a low complication rate, demonstrating a strong safety profile. In the robotic bronchoscopy segment for pulmonary applications, Galaxy holds roughly 5% market share and remains in a phase of rapid growth.

From a market standpoint, the global natural orifice surgical robotics market is expected to surpass USD 80 billion, with the lung cancer biopsy sub-segment alone representing approximately USD 6 billion. China's surgical robotics market is projected to sustain a 30–36% compound annual growth rate over the coming years, with select early-stage innovative sub-segments growing even faster. More critically, the shift toward non-invasive approaches is continuously expanding the addressable patient population—patients previously excluded due to procedural risk or diagnostic difficulty are steadily entering the diagnosable and treatable pool.

The core value of Noah Medical's chosen path lies in combining assured demand with room for expansion: on one hand, lung cancer diagnosis and treatment represents a large and steadily growing base of inelastic clinical need; on the other, the precision access and localization capabilities built on the natural orifice approach carry platform potential for replication across other specialties.

Noah Medical is not positioned in a single-product niche. It sits along a capability pathway with the potential for progressive, multi-specialty expansion.

Conclusion

The investment logic of medical robotics ultimately comes down to a judgment about problem hierarchy. Amid similar levels of technological excitement and market narrative, the companies that choose to tackle clinical problems not yet effectively solved—and that create new medical capabilities through technology—are the ones most likely to deliver true long-term structural value.

Noah Medical is a representative company worthy of sustained attention within this framework. Subsequent articles in this series will further examine its technology pathway, clinical evidence, and commercialization trajectory.

— This is the first article in the Noah Medical deep-dive research series

Robust Revenue Growth, Drastically Narrowed Losses, and Continuous Improvement in Operational Quality

In 2025, Cryofocus recorded a revenue of RMB 95.27 million, representing a surging increase of 78.0% compared to RMB 53.53 million in the same period of 2024. The loss for the year was significantly narrowed by 60.0% to RMB 44.46 million, down from RMB 111.28 million in 2024, showcasing the Company's outstanding operational efficiency and cost-control capabilities.

The Company's overall gross profit reached RMB 63.98 million, a year-on-year increase of 66.6%, while the gross profit margin was maintained at a healthy level of 67.2%. During the reporting period, Cryofocus continued to optimize its R&D efficiency. R&D expenses decreased by 58.6% year-on-year to RMB 30.44 million, primarily due to the reduction in investments following the successful NMPA approval of certain products, as well as the optimization of staff costs. This reflects the steady transition of the Company's R&D pipeline from an early-stage investment phase to a late-stage harvest phase.

Comprehensive Acceleration of the Cryotherapy Product Matrix with Respiratory Intervention as the Core Growth Engine The strong financial growth was primarily driven by the commercial volume ramp-up of the Company's cryotherapy product pipeline, which is built upon its unique liquid nitrogen cryoablation technology and advanced flexible catheter technology platforms. Notably, the respiratory intervention product pipeline delivered a stellar performance, acting as the absolute main driving force for revenue growth.

In March 2025, the Company's Malignant Stenosis Cryoablation System received approval from the National Medical Products Administration (NMPA) and was successfully commercialized in China in May of the same year, with sales volume climbing rapidly. In addition, the sales of the previously commercialized Cryoadhesion System continued to grow. Meanwhile, the Company further deepened its distribution partnership with the international medical giant Boston Scientific (BSC) in the Chinese market, which contributed considerable incremental revenue.

More notably, the Company's Asthma Cryoablation System was granted designation as a "Breakthrough Medical Device" by the U.S. Food and Drug Administration (FDA) in July 2025. This marks an international authoritative recognition of its innovative technology, laying a solid foundation for its future expansion into the global market.

Successful Share Placement Fortifies Financial Foundation to Facilitate Global Expansion

To support future R&D and market expansion, the Company successfully completed the placement of new H shares to specific investors in January 2026. A total of 5,595,000 H shares were issued, raising net proceeds of approximately HK$29.73 million. Cryofocus plans to utilize the funds primarily for the R&D, manufacturing, and commercialization of minimally-invasive interventional products related to vascular intervention, respiratory intervention, and cancer intervention, as well as to provide financial backing for the potential overseas business expansion of these commercialized products.

This financing not only bolstered the Company's cash reserves, securing a solid financial guarantee for the clinical development and global registration of subsequent high-value pipeline products—such as the Peri-Pulmonary Nodule Cryoablation System, COPD Cryospray System, Asthma Cryoablation System, and the Cryo-RDN System for resistant hypertension—but also underscored the strong confidence of professional institutional investors in the Company’s technology platform and long-term prospects.

Looking Ahead: Platform Advantages Highlighted, Striving to Become a Global Cryotherapy Leader

Leveraging its unique "One Platform, Multiple Tracks" business model, Cryofocus has built a robust product pipeline covering multiple therapeutic areas, including vascular intervention, respiratory intervention, and cancer intervention. The Company currently possesses a comprehensive pipeline comprising 25 products and product candidates, 11 of which have already been commercialized. As more products progressively enter late-stage clinical trials and the regulatory approval phase, the value of the Company's platform is expected to be continuously unlocked.

Looking ahead, Cryofocus stated that it will continue to execute its clear strategies: rapidly advancing the clinical development and commercialization of product candidates; further expanding the product portfolio based on its core technology platform; continuously investing in underlying and supporting technologies; and selectively expanding its worldwide footprint. The Company is steadily transitioning from an R&D-driven approach to a dual-engine model driven by both R&D and commercialization, taking solid steps toward its vision of becoming a "global medical device platform in the field of minimally-invasive interventional cryotherapy."

RESULTS HIGHLIGHTS:

- The Revenue for the year ended 31 December 2025 was approximately HK$3,736.5 million, representing an increase of approximately 11.1% as compared with the same period last year.

- The Gross Profit Margin for the year ended 31 December 2025 was approximately 55.8%; the gross profit was approximately HK$2,085.0 million, representing an increase of approximately 15.9% as compared with the same period last year.

- The Group’s EBITDA for the year ended 31 December 2025 was approximately HK$938.1 million, representing an increase of approximately 32.4% as compared with the same period last year.

- The Group’s net profit for the year ended 31 December 2025 was approximately HK$601.2 million, representing an increase of approximately 47.7% as compared with the same period last year.

- Basic earnings per share for the year ended 31 December 2025 amounted to approximately HK63.7 cents, representing an increase of approximately 47.5% as compared with the same period last year.

- The Board recommended the payment of a final dividend of HK15.0 cents per ordinary share for the year ended 31 December 2025.

- For the year ended 31 December 2025, the Group recorded approximately 1,039,000 cases digital solution cases produced from the Group’s production facilities in Mainland China, Thailand and Vietnam, reflecting an increase of 32.7% as compared with the same period in 2024 as a result of our clients’ continued adoption of intra-oral scanners.

HONG KONG, Mar 27, 2026 - (ACN Newswire) - 26 March 2026, Modern Dental Group Limited (“Modern Dental” or “the Group”, stock code: 03600.HK), a leading global dental prosthetic device provider, announces its annual results for the year ended 31 December 2025 (“the year”).

During the year ended 31 December 2025, the Group’s multi-dimensional strategies and continuous enhancement of operational efficiency and productivity as supported by the ongoing trend of digitalization in the dental industry have resulted in the Group reporting record revenues, net profit and EBITDA numbers during this period. This occurred in a period of challenging macro-economic environment with general softness in demand for dental procedures and trade war uncertainties. The Group has been proactive in its approach to deal with the unprecedented international trade environment leveraging its international production facilities located in Thailand, Vietnam and Mainland China.

The global digitalization trend continues to drive consolidation within the dental prosthetics industry, enabling the Group to further expand its market share. Our ongoing digital transformation initiatives are enhancing both customer and patient experiences while improving operational efficiency, further differentiating the Group from competitors and positioning us to outperform industry peers. The Group’s underlying fundamentals remain solid, and we are well positioned to capitalize on emerging opportunities going forward.

European Businesses

During the year ended 31 December 2025, the European market recorded a revenue of approximately HK$1,887.0 million, representing an increase of approximately HK$268.0 million as compared with the year ended 31 December 2024. This geographic market accounted for 50.5% of the Group’s total revenue. The increase of revenue from the European market was mainly attributable to the increase in sales order volume driven by the launch of new products, such as digital dentures, and our state-of-the-art digital workflows.

The Group has been the frontrunner to provide comprehensive digital solutions offerings, ranging from numerous minimal invasive and aesthetic prosthetic solutions to intra-oral scanners and clear aligners, and is well positioned to capture the opportunities arising from the accelerated digitalization trend of the dental industry. The Group continues to aggressively gain market share from international and domestic competitors through our established dental ecosystem solutions with a focus on education and digitalization, which is available within close proximity to our clients; effectively meeting our clients’ high expectations through our various onshore and offshore resources. The Group is committed and will continue to equip ourselves to provide the state-of-the-art digital solutions offerings to the dental community in the market.

North American Businesses

During the year ended 31 December 2025, the North American market recorded a revenue of approximately HK$696.4 million, representing a decrease of approximately HK$55.7 million as compared with the year ended 31 December 2024. This geographic market accounted for approximately 18.6% of the Group’s total revenue.

A significant portion of our business in the North America region comprises higher-end products manufactured domestically by MicroDental Laboratories, Inc. and its subsidiaries (“MicroDental Group”). While demand for discretionary cosmetic treatments remained soft throughout 2025, our centralized digital workflows and network-wide production oversight enabled us to deliver enhanced service quality and operational efficiencies to our North American customers.

Our diversified supply bases in the US, China, Vietnam and Thailand continue to provide greater flexibility to navigate US tariff uncertainties — an advantage that sets us apart from competitors. Although digitalization of imported product lines drove growth in mass market cases, implementation of the US tariff in April 2025 introduced new uncertainties and contributed to a slow growth in sales for our import-focused business unit.

Greater China Businesses

For the year ended 31 December 2025, the Greater China market recorded a revenue of approximately HK$615.4 million, representing a decrease of approximately HK$46.8 million as compared with the year ended 31 December 2024. This geographic market accounted for approximately 16.5% of the Group’s total revenue.

The Mainland China market faced headwinds from the volume-based procurement policies and a prolonged period of intense price competition and the situation started to stabilize in the second half of 2025. This also led to aggressive promotions for dental implant treatments by Mainland China dental clinics in Hong Kong (which experienced a notable decrease in patient visits in Hong Kong). The Group’s has deliberately pivoted away from low-margin segments and stay focused on serving mid- and high-value customers, ensuring long-term sustainable profitability of the Group’s business.

The Group is optimistic in its mid/long-term outlook for this market in particular where the latest procurement-related government measures are expected to (i) standardize the pricing of dental prosthetics and develop price transparency, which would level the playing field; (ii) allow the Group’s leading brand name and reputation to be a key consideration for its client and customer; and (iii) have the Group benefit from its large production team and its ability to allocate resources efficiently according to the customer or client.

Australian Businesses

For the year ended 31 December 2025, the Australian market recorded a revenue of approximately HK$289.1 million, representing an increase of approximately HK$24.4 million as compared with the year ended 31 December 2024. This geographic market accounted for approximately 7.7% of the Group’s total revenue. The increase in revenue from Australia reflected a strong uptake of new digital products driven by the digitalization trend in dental industry and the revenue contribution from the acquisition of Digital Sleep which is partially offset by the depreciation of AUD against HK$ by 2.4% compared with the year ended 31 December 2024.

Through our various brands, which offer onshore-and offshore-made products, at multiple price points ranging from economy and standard to premium/boutique, the Group is able to effectively penetrate the entire Australian market. We have invested in local production capacity to provide faster service to our customers, and to provide choices around where the products are made. The Group is one of the largest players in the Australian market and is a preferred supplier to the major corporate dental groups in the market.

Other Markets

Other markets primarily include Thailand, Indian Ocean countries, Malaysia, Taiwan and Singapore. For the year ended 31 December 2025, these markets recorded a revenue of approximately HK$248.9 million, representing an increase of approximately HK$182.4 million as compared with the year ended 31 December 2024. This geographic market accounted for approximately 6.7% of the Group’s total revenue. The increase in revenue from Other markets was primarily driven by the revenue contribution from the newly acquired Hexa Ceram.

Future Prospects and Strategies

The global macroeconomic environment remains uncertain, with geopolitical tensions and potential tariff changes continuing to create headwinds. However, the Group’s geographically diversified production footprint and global distribution network position us strongly to navigate these challenges. Unlike many competitors reliant on single-country manufacturing, our operations across China, Vietnam and Thailand (including the newly acquired Hexa Ceram) provide superior resilience and flexibility. This strategy, combined with our ability to adapt quickly to local market conditions, enables the Group to mitigate risks and capitalize on opportunities across regions.

The dental industry has continued to demonstrate remarkable resilience, underpinned by irreversible demographic trends, including aging populations and increasing awareness of oral health, which drive consistent long-term demand. Building on our record 2025 performance, the Group is well placed to sustain momentum and further strengthen its market leadership.

Digitalization remains an irreversible industry trend that is accelerating consolidation of the dental prosthetics industry. We are at the forefront of this transformation, with digital solution cases now representing approximately 35–40% of total volume. Our centralized digital workflows, intra-oral scanner partnerships, proprietary solutions and global education centers have enhanced operational efficiency, reduced turnaround times and delivered superior customer experiences. These initiatives create high entry barriers and will continue to drive margin expansion and market share gains in the coming years.

Following the successful integration of Hexa Ceram (Thailand’s largest dental laboratory, acquired in January 2025) and Digital Sleep Design (Proprietary nylon oral appliance to treat obstructive sleep apnea), our Southeast Asian presence and specialized capabilities have been significantly strengthened. This expansion, coupled with our diversified supply bases in the US, China, Vietnam, and Thailand, provides enhanced flexibility to address potential trade and geopolitical risks while supporting faster regional delivery.

Looking ahead, the Group remains committed to reinforcing its worldwide leading position through a multi-dimensional approach. We will continue to pursue selective acquisitions, joint ventures and partnerships to expand and complement our product offerings, particularly in our high-growth clear aligner, Trioclear, while strengthening our distribution and sales networks. Ongoing investments in mass-scale production facilities, AI, automation, research and development, and digital innovation will drive efficiency gains and secure our position at the forefront of the industry.

About Modern Dental Group

Modern Dental Group Limited (Stock code: 03600.HK) is a leading global dental prosthetics provider, distributor and consultant with a focus on providing custom-made prostheses to customers in the growing prosthetics industry. Our product portfolio is broadly categorized into three product lines: fixed prosthetic devices, such as crowns and bridges; removable prosthetic devices, such as removable dentures; and other devices, such as orthodontic devices, sports guards, clear aligners, and anti-snoring devices. Modern Dental Group has a global portfolio of respected brands, including Labocast, Permadental and Elysee Dental in Western Europe, YZJ Dental in China, Modern Dental Lab in Hong Kong, Modern Dental USA and MicroDental in the United States, Modern Dental Pacific in Australia and New Zealand, Modern Dental SG in Singapore, Modern Dental TW in Taiwan, Apex Digital Dental in Malaysia and Hexa Ceram in Thailand. We have grown these brands by providing premium and consistent quality products and superior customer service. We have more than 80 service centers in over 28 countries and serve over 35,000 customers.

Toronto, ON, Mar 25, 2026 - (ACN Newswire) - Aleen Inc. (CSE: ALEN-U), a digital wellness company, has introduced a new data layer within its Personal Wellness Account, designed to enhance how its AI assistant interprets and structures wellness data.

As part of its ongoing product development, Aleen Inc. has implemented a biomarker extraction approach that enables the system to process user-provided data and identify key indicators in a more structured way. This includes the use of a dedicated AI agent that processes documents page by page and extracts relevant biomarkers from wellness data sources.

In addition to extraction, Aleen Inc. is developing a standardized structure for each biomarker, including its name, value, unit of measurement, and reference range. These structured data elements are now reflected within the Personal Wellness Account interface. Users will be able to view the total number of detected biomarkers and potential deviations directly within the file list, while a dedicated “Biomarkers” tab in the detailed view provides expanded access to the data in both table and panel formats, along with search and filtering capabilities.

This development represents a step toward more structured data environments within Aleen’s ecosystem, supporting improved organization, accessibility, and interaction with wellness data. The introduction of this layer may also contribute to future enhancements in how the system identifies patterns and supports user-centered insights. This update reflects Aleen Inc.’s continued focus on building scalable data architecture and advancing its Personal Wellness Account as a structured, AI-assisted environment for working with wellness data.

About Aleen Inc.

Aleen Inc. operates as a digital wellness and well-being insights company. Its platform transforms personal wellness information into simple, personalized insights that promote greater self-awareness and balance in daily life. Aleen’s mission is to empower individuals with knowledge and clarity through responsible use of technology and data.

For more information, visit www.aleen.ca.

Forward-Looking Statement

This press release contains forward-looking statements regarding future plans and developments by Aleen Inc. These statements are based on current expectations and assumptions and are subject to risks and uncertainties that could cause actual results to differ materially. Aleen Inc. undertakes no obligation to update or revise these statements except as required by law.

HONG KONG, Mar 25, 2026 - (ACN Newswire) - On March 25, 2026, Hengrui Pharma (600276.SH; 01276.HK) announced robust financial results for the full year 2025, fueled by its dual strategy of innovation and globalization. Revenue increased 13.02% year-on-year to RMB 31.63 billion, and net profit attributable to shareholders increased by 21.69% to RMB 7.71 billion.

Innovation remained the engine of Hengrui’s growth: Innovative drug sales increased by 26.09% year-on-year to RMB 16.34 billion, contributing 58.34% to total drug sales. This was driven by a robust pipeline across therapeutic areas, with oncology products contributing RMB 13.24 billion in revenue (+18.52% YoY), and non-oncology products contributing RMB 3.10 billion in revenue (+73.36% YoY).

Hengrui kept innovation at its core, with R&D expenditure reaching RMB 8.72 billion in 2025, accounting for 27.58% of total revenue, of which RMB 6.96 billion was expensed. During the year, the company secured seven approvals for Class 1 innovative drug, one for a Class 2 innovative drug, and six for new indications of marketed innovative drugs. The pace of regulatory progress accelerated with 15 NDA/BLAs accepted by the NMPA. Meanwhile, 28 drug candidates entered Phase III clinical trials, 61 progressed to Phase II, and 28 NMEs entered Phase I for the first time.

The company currently has over 100 proprietary innovative products in clinical development and is conducting more than 400 clinical trials. This robust portfolio will be further supported by approximately 53 innovative product and indication approvals anticipated during 2026-2028.

2025 marked another year of accelerated progress in Hengrui's global expansion. Licensing revenue rose 25.62% to RMB 3.39 billion, cementing the growing global recognition and value of the company’s innovative portfolio. During the year, the company completed five overseas business development transactions for innovative drugs with leading MNCs and biotechs, highlighted by a strategic collaboration with GSK. In parallel, the company continued to advance its self-developed assets and global regulatory efforts. Multiple innovative drugs had their first global clinical trials initiated, ranging from Phase I to III.

Additionally, Hengrui successfully listed on the Hong Kong Stock Exchange, raising total gross proceeds of HK$11.4 billion (US$1.5 billion), including the over-allotment option — marking the largest pharmaceutical IPO in Hong Kong in the past five years and further strengthening its access to global capital.

Looking ahead, Hengrui will continue to focus on addressing unmet clinical needs with its differentiated innovative portfolio, placing equal emphasis on independent R&D and open collaboration to expand access to innovative drugs for patients worldwide.

About Hengrui Pharma

Hengrui Pharma is an innovative, global pharmaceutical company dedicated to the research, development and commercialization of high-quality medicines to address unmet clinical needs. Its therapeutic areas of focus include oncology, metabolic and cardiovascular diseases, immunological and respiratory diseases, and neuroscience. Driven by a patient-focused philosophy since its founding in 1970, Hengrui Pharma remains committed to advancing human health by striving to conquer diseases, improve health, and extend lives through the power of science and technology.

Forward-Looking Statements

This press release contains forward-looking statements, including statements about the company's future growth prospects and pipeline potential. These statements are based on current expectations and assumptions and do not guarantee future performance. Actual results, developments, and business decisions may differ materially from these forward-looking statements. All information in this press release is as of the date of this press release, and Hengrui undertakes no duty to update such information unless required by law.

Toronto, ON, March 18, 2026 (ACN Newswire) - Aleen Inc. (CSE: ALEN-U), a digital wellness company, is currently exploring data standardization approaches that may support the continued development of its Personal Wellness Account.

As part of its regular internal research initiatives aimed at refining and differentiating its digital products, Aleen Inc. is currently exploring the potential relevance of the LOINC framework. This widely recognized standard provides structured naming conventions that help organize and unify the identification of wellness-related indicators across digital environments.

By studying the principles of standardized data structures, Aleen Inc. seeks to better understand how consistent terminology and classification models can contribute to more organized wellness data environments. Standardization can serve as a foundational layer for future system capabilities, enabling digital systems to observe patterns, compare information across datasets, and identify relationships within wellness data over time.

Insights from this research may inform potential improvements within Aleen’s developing infrastructure, including the company’s Personal Wellness Account environment and its evolving Mindful Wellness Database. These exploratory efforts are intended to support more structured wellness tracking and clearer organization of user-centered insights while maintaining Aleen’s non-medical framework.

This research initiative reflects Aleen Inc.’s continued commitment to responsible innovation, thoughtful data architecture, and the gradual expansion of its digital wellness technologies designed to provide accessible, AI-assisted wellness insights.

About Aleen Inc.

Aleen Inc. operates as a digital wellness and well-being insights company. Its platform transforms personal wellness information into simple, personalized insights that promote greater self-awareness and balance in daily life. Aleen’s mission is to empower individuals with knowledge and clarity through responsible use of technology and data.

For more information, visit www.aleen.ca.

Forward-Looking Statement

This press release contains forward-looking statements regarding future plans and developments by Aleen Inc. These statements are based on current expectations and assumptions and are subject to risks and uncertainties that could cause actual results to differ materially. Aleen Inc. undertakes no obligation to update or revise these statements except as required by law.

SHENZHEN, CHINA, Mar 13, 2026 - (ACN Newswire) - China Medical System Holdings Limited (“CMS”, or the “Group”) is pleased to announce that on 13 March 2026, new drug for renal anaemia Desidustat Tablets (the “Product”) has been approved for marketing in China by the National Medical Products Administration of the People’s Republic of China (NMPA). The Product is a novel, oral HypoxiaInducible Factor-Prolyl Hydroxylase Inhibitor (HIF-PHI) for treating anaemia in non-dialysis adult, Chronic Kidney Disease (CKD) patients.

The approval of Desidustat Tablets will further strengthen the Group’s overall layout in the field of nephrology, and synergize with the marketed innovative drug Velphoro (Sucroferric Oxyhydroxide Chewable Tablets, indicated for CKD hyperphosphatemia). Through the efficient linkage of nephrology expert resources and channel networks, the Group is expected to rapidly promote the large-scale clinical application of Desidustat Tablets, providing differentiated treatment options for Chinese CKD patients with renal anaemia and making a positive contribution to the Group’s performance.

More information about Desidustat Tablets and Renal Anaemia

As a novel oral HIF-PHI, the Product’s mechanism of action promotes erythropoiesis through increasing endogenous erythropoietin, improving iron availability and reducing hepcidin. Its China Phase III clinical trial has demonstrated positive results. The primary endpoint of the haemoglobin (Hb) mean change from baseline to Week 7-9 has indicated that, Desidustat is more effective than placebo in increasing Hb level. Results from the extension study demonstrate that the Product can maintain Hb level within the target range over the long term with acceptable safety. In addition, the Product significantly reduces hepcidin levels and ameliorates iron metabolism disorders.

There is still a large unmet need in the treatment of anaemia in CKD patients in China. It is estimated that there are more than 120 million CKD patients in China[1]. Anaemia is one of the frequent complications of CKD, which exhibits a progressively increasing incidence with disease progression. A survey in China showed that the prevalences of anaemia in patients at CKD stage 1 to 5 were 22.0%, 37.0%, 45.4%, 85.1%, and 98.2%, respectively[2]. The target-achieving rate (the Hb level reaching the target value (110~120g / L)) has increased to 51.5% for haemodialysis CKD patients with anaemia[3], but is still only 8.2% for anaemia patients in non-dialysis CKD[4]. The Product is administrated orally, thus expecting to improve the treatment compliance of patients and to meet the unmet treatment needs in the field of CKD anaemia.

Desidustat Tablets have been approved for marketing in India.

CMS INTERNATIONAL DEVELOPMENT AND MANAGEMENT LIMITED, a wholly-owned subsidiary of the Group, obtained an exclusive license for the Product from Zydus Lifesciences Limited (earlier known as Cadila Healthcare Limited) pursuant to a License Agreement with an effective date of 20 January 2020.

The Group adheres to its core strategy of “innovation-driven”, having established a tiered and multi-dimensional innovation product portfolio with abundant reserves: 7 new drugs have been approved for marketing, 6 are currently under marketing review, and nearly 20 projects are about to initiate or are progressing through clinical trials. Through a dual-engine innovation approach combining collaborative development and in-house R&D, the Group continuously enriches its innovative pipeline centered on first-in-class (FIC) and best-in-class (BIC) products, efficiently advancing clinical development and commercialization. Moving forward, CMS will remain clinical needs-driven to deliver more quality pharmaceutical solutions, steadfastly advancing toward the goal of becoming a specialty-focused, innovation-excellent multinational pharmaceutical enterprise.

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the Cardiovascular-Kidney-Metabolic/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.

Reference

1. ZhangL, WangF, WangL, et al. Prevalence of chronic kidney disease in China: a cross-sectional survey[J]. Lancet, 2012, 379(9818):815-822. DOI: 10.1016/S0140-6736(12)60033-6

2. Chinese Expert Consensus on the Diagnosis and Treatment of Renal Anemia (2014 Revised Edition)[J]. Chinese Journal of Nephrology, 2014, 30(9): 712-716. DOI: 10.3760/cma.j.issn.1001-7097.2014.09.015

3. 19th CSN Critical Care & Blood Purification Congress, Chinese Medical Association (July 2-5, 2025)

4. Chinese Expert Consensus on the Diagnosis and Treatment of Renal Anemia (2018 Revised Edition)[J]. Chinese Journal of Nephrology, 2018, 34(11): 860-866. DOI: 10.3760/cma.j.issn.1001-7097.2018.11.012

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

Media Contact
Brand: China Medical System Holdings Ltd.
Contact: CMS Investor Relations
Website: https://web.cms.net.cn/en/home/

SHENZHEN, CHINA, Mar 13, 2026 - (ACN Newswire) - On 12 March 2026, China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that its subsidiary, Dermavon Holdings Limited (“Dermavon”, an innovative pharmaceutical company specialized in skin health, which is applying for a separate listing on the Main Board of The Stock Exchange of Hong Kong Limited) has its innovative prescription medicine ruxolitinib phosphate cream (Lumirix®) (the “Product”, marketed as Opzelura® in the U.S., Europe and Canada) recorded the initial prescriptions for vitiligo patients across 30 provincial-level regions. The prescriptions cover approximately a thousand influential public and private medical institutions in the field of skin health and disease management, including Huashan Hospital, Fudan University, Shanghai Skin Disease Hospital, Dermatology Hospital of Southern Medical University, Second People's Hospital of Chengdu, The First Bethune Hospital of Jilin University, The Second Xiangya Hospital of Central South University, United Family Healthcare Group, among others*. Meanwhile, the Product has become concurrently accessible via over 1,300 offline drugstores as well as JD.com e-commerce platform. *Hospital rankings are listed in no particular order.

As the first topical JAK inhibitor approved in China for the treatment of vitiligo, ruxolitinib phosphate cream has officially launched its large-scale clinical application today, marking a breakthrough in China’s vitiligo treatment landscape and ushering in a new era of precision targeted therapy for vitiligo. Supported by safety and efficacy fully demonstrated in clinical studies, the Product is expected to bring new hope for repigmentation to millions of vitiligo patients.

The rapid commercialization progress of ruxolitinib phosphate cream underscores strong product operation capabilities of CMS (including Dermavon), while also reflecting the robust supports from China’s regulatory reforms in accelerating patient access to clinically urgently needed innovative drugs. Benefiting from the integrated healthcare ecosystem of the Hainan Free Trade Port and the “Urgently Needed Imported Drugs for Clinical Use” policy, the Product initiated pilot clinical use in August 2023 at Boao Super Hospital within the Boao Lecheng International Medical Tourism Pilot Zone. Pilot usage subsequently expanded to designated medical institutions across the Guangdong–Hong Kong–Macao Greater Bay Area, Beijing-Tianjin region and other regions. In accordance with the relevant regulations of China’s real-world data application pilot project, as well as supported by the Hainan Provincial Medical Products Administration and the Administration of the Boao Lecheng International Medical Tourism Pilot Zone, the Product has accumulated real-world clinical data in China under pilot application, significantly accelerating its clinical, registration and approval timelines. The Product received its Drug Registration Certificate on January 30, 2026 (approval date: January 27, 2026).

Following its approval, in less than 1.5 months (including the Chinese New Year holiday), the initial prescriptions for ruxolitinib phosphate cream have been issued across multiple regions and hospitals, reflecting the highly efficient collaboration and concerted efforts among CMS teams, regulatory authorities and business partners. With robust support from the cross-departmental coordination mechanism of the Beijing Daxing Airport Economic Zone Joint Administrative Committee, once import conditions were met, the Product completed customs clearance approval, sampling and related customs procedures within 24 hours, and obtained the drug testing report within 7 working days, representing efficient execution and acceleration for the innovative drugs in China. During this process, the Beijing Municipal Medical Products Administration proactively provided end-to-end policy guidance; the government service center has efficiently completed customs clearance filing; the Beijing Institute for Drug Control has conducted methodological pre-testing to accelerate timelines for innovative drug, and continuous worked during the Chinese Spring Festival; and Daxing Airport Customs provided specialized pre-guidance on declaration and swiftly completed customs review and release. Through parallel workflows and coordinated execution, all parties collectively pressed the “fast-forward button” for the Product’s commercialization, helping this urgently needed innovative therapy reach patients faster.

As the Product enters the large-scale clinical application stage, it is expected to further strengthen Dermavon’s comprehensive dermatology solutions and brand value. Building on its leadership in skin health, Dermavon will continue to improve accessibility of ruxolitinib phosphate cream to benefit more vitiligo patients and steadfastly safeguard public skin health through innovation.

About Vitiligo

Vitiligo is a chronic autoimmune disease characterized by depigmentation of the skin, which results from the loss of pigment-producing cells known as melanocytes. The discolored areas usually get bigger with time and the condition could influence skin on any part of the patients’ body. Vitiligo usually affects the appearance of patients, especially on exposed areas such as the face and neck. According to a study that involved over 1,000 diagnosed vitiligo patients, over 45% of patients have facial involvement, and over 20% of patients have neck involvement[1].The obvious presence of white patches may make patients feel that their appearance has been compromised, which in turn materially affects their social life, and is associated with a significantly higher incidence of mental health disorders; accordingly, there is an urgent need for effective treatment options for vitiligo[2].

It is estimated that there are approximately 10.3 million vitiligo patients in China and non-segmental vitiligo patients account for approximately 8.2 million[1]. Existing therapies, such as topical corticosteroids (TCS) and topical calcineurin inhibitors (TCIs), have clinical limitations, with adverse reactions or limited efficacy with long-term use. Ruxolitinib phosphate cream successfully fills the gap in targeted drug treatment for vitiligo and is of great landmark significance.

More Information About Ruxolitinib Phosphate Cream

Ruxolitinib phosphate cream (Opzelura®), a novel cream formulation of the selective JAK1/JAK2 inhibitor ruxolitinib developed by Incyte, is the first and only drug approved for the repigmentation of non-segmental vitiligo by the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA)[3,4]. In the U.S., the Product is indicated for the topical treatment of nonsegmental vitiligo in adult and pediatric patients aged 12 years and older, and for the short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis (AD) in non-immunocompromised adult and pediatric patients aged 2 years and older whose disease is not well controlled with topical prescription therapies, or when those therapies are not advisable. In Europe, ruxolitinib phosphate cream is approved for the topical treatment of non-segmental vitiligo with facial involvement in adults and adolescents from 12 years of age. In China, besides vitiligo indication, the product’s NDA for the treatment of mild-to-moderate AD in adults and pediatric patients aged 2 years and older is also under regulatory review, which has been included in the Priority Review List and is expected to accelerate the Product’s AD review process for marketing approval.

The Group, through the subsidiary of Dermavon entered into a Collaboration and License Agreement with Incyte for ruxolitinib phosphate cream on 2 December 2022, obtaining an exclusive license to develop, register and commercialize the Product in Mainland China, Hong Kong Special Administrative Region, Macau Special Administrative Region, Taiwan Region and eleven Southeast Asian countries (the “Territory”) and a non-exclusive license to manufacture the Product in the Territory. The subsidiary of Dermavon has sublicensed the relevant rights for the Product outside of Mainland China to the Group (excluding Dermavon and its subsidiary).

Incyte has worldwide rights for the development and commercialization of ruxolitinib phosphate cream (excluding territories in which exclusive rights have already been licensed), marketed in the United States and Europe as Opzelura®. Opzelura® and the Opzelura® logo are registered trademarks of Incyte.

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardiovascular-kidney-metabolic/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.

Reference:

1. China Insights Consultancy’s industrial report 

2. Wang G, Qiu D, Yang H, Liu W. The prevalence and odds of depression in patients with vitiligo: a meta-analysis[J]. Journal of the European Academy of Dermatology and Venereology, 2018,32(8):1343-1351. DOI:10.1111/jdv.14739. 

3. The U.S. FDA approval information can be found on the Incyte official website, as follows:

https://investor.incyte.com/news-releases/news-release-details/incyte-announces-us-fda-approval-opzeluratm-ruxolitinib-cream

4. The EMA approval information can be found on the Incyte official website, as follows:

https://investor.incyte.com/news-releases/news-release-details/incyte-announces-european-commission-approval-opzelurar

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

Media Contact
Brand: China Medical System Holdings Ltd.
Contact: CMS Investor Relations
Website: https://web.cms.net.cn/en/home/

Results Highlights:

• Revenue increased by 10.0% year-on-year to a record high of US$180.5 million, marking the fifth consecutive year of record-setting revenue performance.
• Sales volume hit a new high of 2.02 million units, representing a year-on-year increase of 16.2%.
• Gross profit rose by 7.0% to a record of US$122.4 million; profit attributable to owners of the Company rose by 5.5% to US$41.9 million.
• The Board has proposed a final cash dividend of HK12 cents per share, bringing the total cash dividend for the Year to HK27 cents per share alongside special dividend, representing a payout ratio of 68.4%.
• The Group remains in a robust financial position, with cash and bank balances of US$228.7 million at the end of the year for supporting potential acquisitions and the construction of new production facilities.
• Maintained revenue growth in major markets, with the Asia-Pacific market at 15.7%, the EMEA markets at 19.6%, and the US market at 37.0%.
• The Group actively leverages its sales network and expertise to assist high-quality medical device peers in selling their products globally, while diversifying its own product portfolio. One of the collaborative products has already been launched in Hong Kong, Malaysia, Germany, and Spain, and is progressively being rolled out to more markets in the APAC and EMEA regions.

HONG KONG, Mar 12, 2026 - (ACN Newswire) – OrbusNeich Medical Group Holdings Limited (“OrbusNeich” or the “Group”; stock code: 6929), a multinational medical device company specializing in interventional devices for percutaneous coronary intervention (“PCI”) and percutaneous transluminal angioplasty (“PTA”) procedures, today announced its annual results for the year ended December 31, 2025 (“FY2025” or the “Year”). Despite significant external challenges, the Group demonstrated remarkable resilience, achieving historic highs in revenue, sales volume, and gross profit, along with improved net profit.

During the Year, OrbusNeich’s investments to strengthen its global sales and marketing capabilities, as well as expand product offerings, continued to yield positive results. The Group achieved revenue growth for the fifth consecutive year, reaching a record high of US$180.5 million. Additionally, sales volume in FY2025 hit a new high of 2.02 million units, representing a year-on-year growth of 16.2%, which included an increase of 13.1% from proprietary products and 34.9% from third-party products. Gross profit, up by 7.0% year-on-year, reached a record high of approximately US$122.4 million, with profit attributable to owners of the Company increasing by 5.5% to $41.9 million, and basic earnings per share rising by 5.8% to US5.09 cents.

As at December 31, 2025, the Group maintained a strong financial position with cash and bank balances amounting to US$228.7 million. Taking into consideration OrbusNeich’s solid operating performance, healthy cash reserves and future capital requirements, the Board has proposed a final cash dividend of HK12 cents per share (2024: HK10 cents per share), up by 20% year-on-year. Alongside the special cash dividend of HK15 cents per share paid during the Year to celebrate OrbusNeich’s 25th anniversary and express gratitude for shareholders’ long-standing support, the total cash dividend for FY2025 will be HK27 cents per share.

Mr. David Chien, Chairman, Executive Director and Chief Executive Officer of OrbusNeich, said, “Building on 25 years of expertise, OrbusNeich achieved another strong performance in FY2025. Our commitment to product innovation and quality, and the establishment of dedicated local teams in diverse markets ensures that our products benefit vascular disease patients worldwide. During the Year, the Group advanced its strategy of building a comprehensive sales network while forging strategic collaborations, including providing commercialization support for Chinese medical device companies expanding overseas. Meanwhile, construction of our R&D and manufacturing base in Hangzhou is progressing steadily, reflecting our long-term growth ambitions.”

Extensive Global Sales Network Fuels Strong Multi-Regional Revenue and Business Growth

OrbusNeich maintains an extensive sales network covering over 70 countries and regions through its 12 direct sales teams and distributor network, which includes the acquisition of a Taiwan-based distributor during the Year. During FY2025, the APAC region experienced a significant year-on-year increase in revenue of 15.7%, climbing to US$60.5 million, driven by strong performance in existing direct sales markets and the addition of the Taiwan market. Revenue growth in the EMEA region accelerated, rising by 19.6% to US$46.9 million, supported by rapid growth of over 20% in direct sales markets such as Germany, France, and Spain, along with substantial growth in distributor markets. As the impact of tariffs eased and product demand remained strong, revenue from the US market grew by 37.0% year-on-year, reaching US$21.2 million. Meanwhile, revenue from the Japan and PRC markets totaled US$32.3 million and US$17.8 million, respectively.

In the second half of the year, the Group focused on strengthening its market presence in Europe and established a direct sales team in the Netherlands. The Group is establishing another direct sales team in Belgium in 2026, with the goal of achieving direct sales to local hospitals in both markets within the same year.

OrbusNeich’s robust global sales network has attracted various manufacturers to collaborate with the Group on international market expansion. During the Year, the Group strengthened its partnership with SonoScape Medical Corp. by distributing their IVUS products across key APAC and European markets, including direct sales regions like Singapore, Malaysia, France, Germany, Spain, and Switzerland, as well as selected distributor markets in Europe. The IVUS products began generating sales in Hong Kong, Malaysia, Germany, and Spain by the end of FY2025.

Strengthening a Diversified Portfolio via Parallel Global Registrations and Clinical Trials

As at December 31, 2025, OrbusNeich owned more than 220 granted patents and published patent applications in key jurisdictions worldwide, as well as 35 PMDA-approved products, 42 CE-marked products, 20 FDA-cleared or approved products, and 24 NMPA-approved products.

During the Year, the Group achieved progress in product registrations and clinical trials, including:

• Obtained PMDA approvals for Teleport Glide, Scoreflex QUAD, EZGuide LL (Large Lumen), Vascuaid and SIDEPASS, CE Marks for JADE PLUS and Teleport Glide, and NMPA approvals for the GuidingArk guiding catheter and Teleport XT;
• Submitted applications for FDA approval of Teleport Glide, PMDA approvals of Sapphire ULTRA and Sapphire NC ULTRA, and NMPA approvals of Scoreflex TRIO, Teleport Glide, Sapphire NC 24, Sapphire NC ULTRA, Sapphire ULTRA and JADE PLUS;
• Completed patient enrollment for the US clinical trial of Sapphire 3, with product registration expected to be submitted to the FDA in the first half of 2026;
• Completed patient enrolment of clinical registries for eucatech AG’s product eucaLimus and SUPPORT C, while patient enrollment for VITUS is still ongoing, with the goal of renewing CE Marks for these products under MDR by the end of 2027;
• Developing the proprietary coronary paclitaxel drug-coated balloon, Sapphire PTX, with a clinical trial application expected to be submitted to the PMDA in Q1 2026;
• Developing the peripheral scoring balloon, JADE Score, with registration applications expected to be submitted to the PMDA and the FDA in 2026.

Optimizing Global Production Layout for Sustained Long-Term Growth

The Group’s facilities in Shenzhen, the PRC; Hoevelaken, the Netherlands; and Weil am Rhein, Germany, achieved a combined annual production capacity of approximately 2.1 million units of balloons and stents as at December 31, 2025. To meet future production needs, construction of OrbusNeich’s largest R&D and manufacturing facility in Hangzhou, the PRC, is underway. Following the topping-out ceremony in the second half of 2025, marking the completion of construction of the main structure, renovation work has been ongoing since the end of 2025. The new facility is expected to commence operation in 2027, adding an annual production capacity of 2.4 million units.

Mr. Chien concluded, “Looking ahead to 2026, OrbusNeich will continue leveraging its global platform to navigate ongoing external challenges. With the launch of new proprietary and eucatech AG products, rising third-party product sales, and the shift from distribution model to direct sales in certain markets, we expect steady revenue growth in the future. The Group will also explore potential downstream acquisitions in Europe to further consolidate our brand position. Going forward, we aim to sharpen our commercialization edge, maintain leadership in innovation and quality, and explore new business models to drive growth. Ultimately, these initiatives will reinforce our global competitiveness and further our founder, Mr. Teddy Chien’s vision of ‘benefitting humanity’ by improving patients’ quality of life worldwide.”

About OrbusNeich Medical Group Holdings Limited

OrbusNeich is a multinational medical device company specializing in interventional devices for percutaneous coronary intervention (PCI) and percutaneous transluminal angioplasty (PTA) procedures. Headquartered in Hong Kong, China, our Group sells its products in more than 70 countries and regions worldwide. It is also actively expanding into structural heart disease. With an in-house R&D team boasting over 20 years of product development expertise, our Group has developed world-leading proprietary technologies.

For more information, please visit the Group’s official website: https://orbusneich.com/.

Website: https://www.sprg.com.hk/

Website: https://orbusneich.com/